Human adult neurogenesis across the ages: An immunohistochemical study

By C. Dennis, LS Suh, Ml Rodríguez, J. Kril, GT Sutherland. 2016

244 citations recorded by the source corpus.

Neurogenesis in the postnatal human brain occurs in two neurogenic niches; the subventricular zone (SVZ) in the wall of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. The extent to which this physiological process continues into adulthood is an area of ongoing research. This study aimed to characterize markers of cell proliferation and assess the efficacy of antibodies used to identify neurogenesis in both neurogenic niches of the human brain.

Subfields: Developmental Neuroscience, Genetics, Neurology

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In Developmental Neuroscience

In Genetics

Fred H. Gage

In Neurology

Citations in the corpus

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “In humans, some studies suggest that hundreds of new neurons are added to the adult DG every day 11 , while other studies find many fewer putative new neurons 12–14 .”
The role of adult hippocampal neurogenesis in brain health and disease (2018, result): “2 to 59 years revealed that proliferating cells in the SGZ rapidly decline in early childhood [88], consistent with an earlier study [7].”
Human adult neurogenesis: evidence and remaining questions (2018, unknown): “But while Sorrells et al. and several other studies pointed out an age-related decrease in marker overlap and a sharp decline in proliferating cells (Dennis et al., 2016; Knoth et al., 2010; Mathews et al., 2017), Boldrini et al. state that these numbers would hardly change across adulthood.”