High versus low blood-pressure target in patients with septic shock.

By P. Asfar, F. Meziani, Jean-François Hamel, F. Grelon, B. Mégarbane, N. Anguel, J. Mira, P. Dequin, Soizic Gergaud, N. Weiss and 21 more. New England Journal of Medicine, 2014

989 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Nephrology

View Paper: https://www.semanticscholar.org/paper/421d8e837071ad1b94bc4354b29202161e18ee27

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. R. Bellomo
2. John A. Kellum
3. Leo Anthony Celi
4. Shamim Nemati
5. J. Teboul
6. Mitchell M. Levy

In Epidemiology

1. Claudio Ronco
2. John A. Kellum
3. Finale Doshi-Velez
4. Sean M. Bagshaw
5. R. Bellomo
6. Shamim Nemati
7. Michael C. Hughes
8. Joseph D. Futoma

In Nephrology

1. John A. Kellum
2. R. Bellomo
3. Claudio Ronco
4. Sean M. Bagshaw
5. M. Ostermann
6. R. Chang

Citations in the corpus

• Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial. (2016, neutral): “APACHE II score, median (IQR) 24 (19-30) 24 (19-29) 24 (20-30) 23 (18-30) 24 (19-30)”
• Does the "Artificial Intelligence Clinician" learn optimal treatment strategies for sepsis in intensive care? (2019, background): “If a clinician has a septic patient with low MAP (e.g. below 65 mm Hg [7]), they will consider putting them on vasopressors to increase blood pressure.”
• Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial (2019, background): “Intravenous fluid loading per weight, mL/kgf 25 (16-40) 30 (20-43)”
• Sepsis and septic shock. (2018, background): “Asfar and colleagues 89 showed that a higher mean blood-pressure target (80–85 mm Hg) was not associated with better survival compared with a lower target (65–70 mm Hg).”
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “In particular, this “low” MAP target is recommended over higher MAP targets based on the literature.(18,19)”
• POPCORN: Partially Observed Prediction COnstrained ReiNforcement Learning (2020, background): “A MAP of 65mmHg is a common target (Asfar et al., 2014), so if an action is taken and the next MAP is 65 or higher, the next reward is +1, the highest possible value.”
• Acute kidney injury in sepsis (2017, background): “In this regards, increasing mean arterial pressure to levels above 80 mmHg with greater norepinephrine dosage [74] appears to have potential beneficial effects on renal function in patients with premorbid hypertension.”
• Interpretable Off-Policy Evaluation in Reinforcement Learning by Highlighting Influential Transitions (2020, background): “For long ICU stays, we limit to only using information captured during the inital 48 hours after admission, as our intensivist advised that care for hypotension during later periods of an ICU stay often look very different.”