Dialogue between skin microbiota and immunity

By Y. Belkaid, J. Segre. Science, 2014

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How researchers see this paper

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Interaction between microbiota and immunity in health and disease (2020, background): “Whether skin dysbiosis is the cause or consequence of these disorders is not yet clarified, but it has been proposed that locally amplified immune responses to particular skin microbes, or increased microbial load, in the setting of impaired skin barrier and genetic predisposition, might contribute ”
Microbiota in health and diseases (2022, background): “Lugdunin also inhibits other pathogens including Enterococcus faecalis, Listeria monocytogenes, Streptococcus pneumoniae, and Pseudomonas aeruginosa.(57) Overall, understanding the interactions among skin microbiota communities will be beneficial to the control of skin diseases or disorders.”
CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, positive): “The human skin forms a barrier to the external environment that is constantly exposed to colonizing microbiota, invasive pathogens, and allergens (Belkaid and Segre, 2014; Pasparakis et al., 2014).”
Temporal Stability of the Human Skin Microbiome (2016, positive): “These symbiotic organisms play essential roles in lipid metabolism, colonization resistance to transient organisms, and education of the immune system (Belkaid and Segre, 2014; Grice, 2015; Scharschmidt and Fischbach, 2013).”