CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity

By G. Marsicano, S. Goodenough, K. Monory, Heike Hermann, M. Eder, A. Cannich, S. Azad, M. Cascio, S. Gutiérrez, Mario van der Stelt and 7 more. Science, 2003

1,206 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/412982ff763c27540e6a3d83819abe00b5db96fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Guzmán
2. U. Kumar
3. John L. Rubenstein
4. K. Mackie
5. Z. Kokaia
6. K. Monory
7. M. During
8. P. Pacher

In Cognitive Neuroscience

1. U. Kumar
2. John L. Rubenstein
3. K. Mackie
4. Shenglong Zou
5. George Kunos

In Pharmacology

1. U. Kumar
2. Shenglong Zou
3. George Kunos
4. P. Pacher
5. S. Batkai
6. M. Guzmán
7. K. Mackie
8. M. Elphick

Citations in the corpus

• The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “For instance, by using conditional mutagenesis in mice, the relatively low levels of CB1 receptor expression in cortical pyramidal neurons were recently shown to play a central role in the endocannabinoid-mediated protection against excitotoxic seizures (12).”
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “…was suggested to protect against excitotoxicity by various mechanisms, including inhibition of calcium channels and stimulation of potassium channels to decrease neuronal excitability and the activation of extracellular signal regulated kinases (Marsicano et al., 2003; Khaspekov et al., 2004).”
• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system (2010, neutral): “Unlike most other neurotransmitters, which are water soluble and stored in membrane-delineated vesicles before release, the endocannabinoids anandamide and 2-AG are hydrophobic neutral lipids that appear to be biosynthesized and released at the moment of their intended action (on-demand productio”
• The endocannabinoid system drives neural progenitor proliferation (2005, positive): “Thus, eCBs generated on demand on brain injury may result in CB1-induced neuroprotection (9, 10) and NP proliferation (the present study).”
• Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “This has been proposed as a plausible underlying mechanism of CB1R-mediated neuroprotection against excitotoxicity, a prominent pathological process of many neurological disorders, including epilepsy and neurodegenerative diseases [34,130,131].”
• Dendritic excitability and synaptic plasticity. (2008, neutral): “nabinoid signaling in fact promotes epilepsy (498, 533),”
• The endocannabinoid system controls key epileptogenic circuits in the hippocampus. (2006, positive): “Indeed, KA-induced seizures are accompanied by a rapid increase of production of the endocannabinoid anandamide in the hippocampus and activation of CB1 cannabinoid receptors, necessary for the protection against acute excitotoxicity and for the induction of protective intracellular signaling cascad”
• Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation (2005, background): “Furthermore, the involvement of CB1 receptors and their endogenous ligands as neuroprotectants has been demonstrated recently in CB1-null mutants, which are more susceptible to neurodegeneration (Parmentier-Batteur et al., 2002; Marsicano et al., 2003).”
• Distribution of cannabinoid receptors in the central and peripheral nervous system. (2005, background): “cannabinoid-mediated protection in a kainate neurotoxicity model (Marsicano et al. 2003).”