Molecular imprinting: perspectives and applications.

By Lingxin Chen, Xiaoyan Wang, Wenhui Lu, Xiaqing Wu, Jinhua Li. Chemical Society Reviews, 2016

1,876 citations recorded by the source corpus.

Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined. Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

Subfields: Analytical Chemistry, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/410d02264e81d991819a45c2fdd14d0a29a1616d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Analytical Chemistry

1. Lingxin Chen
2. Jinhua Li
3. Yangjun Ding
4. Shasha Wang
5. Sanjukta Patra
6. Satyam Satyam

In Biomedical Engineering

1. Jinhua Li
2. Lingxin Chen

In Molecular Biology

1. Yangjun Ding
2. Shasha Wang
3. Jinhua Li
4. Lingxin Chen
5. C. Pham-Huy
6. Hua-Dong He

Citations in the corpus

• Nanomaterial-based optical sensors for mercury ions (2016, methodology): “Traditionally reported approaches available to monitor Hg 2+ 4 in aqueous samples include atomic absorption spectrometry [5, 6], atomic 5 fluorescence spectrometry [7-9], inductively coupled plasma-mass spectrometry [10, 6 11], fluorometry [12-16] and electrochemical analysis [17-22].”
• Core-shell nanoparticles coated with molecularly imprinted polymers: a review (2016, background): “two main types: Electrochemical sensors and optical sensors [133, 140].”
• Innovations and challenges in adsorption-based wastewater remediation: A comprehensive review (2024, background): “This approach significantly improves the selectivity of the adsorbent by enabling it to recognize and selectively bind to specific molecules, reducing non-specific interactions [48].”
• Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives. (2017, background): “They can be tailor-made to bind template molecules with high selectivity (Chen et al., 2016).”
• Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis. (2018, background): “particularly in sample pretreatment, chromatographic packing materials and chemo/biosensing (Chen et al., 2016).”
• Molecular imprinting technology for microorganism analysis (2018, background): “So, for microorganism analysis, the MIPs based strategy has gained much popularity owing to that the MIPs, compared with natural antibodies, have greater stability and larger sensitivity ranges, and they are also able to adapt to extreme conditions [25].”