Mechanism of NLRP3 inflammasome activation

By F. Sutterwala, Stefanie Haasken, Suzanne L. Cassel. Annals of the New York Academy of Sciences, 2014

679 citations recorded by the source corpus.

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/40f7a76e9ee9bda3c042459395282802ae2c9042

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In Molecular Biology

1. D. Su
2. S. Ghosh
3. Eric I. Elliott
4. Bo-Zong Shao
5. Bin-ze Han
6. Chong Liu
7. F. Sutterwala
8. T. Postler

Citations in the corpus

• Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “The importance of priming for NLRP3 activation is wellreviewed elsewhere (21), but here we provide a brief background and update.”
• NF-κB signaling in inflammation (2017, neutral): “3, 17 Like the pro-IL-1 β gene, the NLRP3 gene is a direct target of NF-κ B and contains NF-κ B-binding sites in its promoter region.”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “…of the NLRP3 inflammasome in LPS-stimulated macrophages, which causes secretion of IL-18 (but also of the pro-inflammatory cytokine IL-1b) and may thus promote maintenance and function of the epithelial barrier (Mariathasan et al., 2006; Sutterwala et al., 2006, 2014; Yaron et al., 2015).”
• NLRP3 inflammasome and its inhibitors: a review (2015, background): “Activation of the NLRP3 inflammasome appears to occur in two steps (Zhong et al., 2013a; Sutterwala et al., 2014; Ozaki et al., 2015; Figure 1).”