Epigenetic reprogramming in plant and animal development

By Suhua Feng, Steven E. Jacobsen, Wolf Reik. Science, 2010

1,168 citations recorded by the source corpus.

Epigenetic modifications of the genome are generally stable in somatic cells of multicellular organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on a genome-wide scale, which includes demethylation of DNA and remodeling of histones and their modifications. The mechanisms of genome-wide erasure of DNA methylation, which involve modifications to 5-methylcytosine and DNA repair, are being unraveled. Epigenetic reprogramming has important roles in imprinting, the natural as well as experimental acquisition of totipotency and pluripotency, control of transposons, and epigenetic inheritance across generations. Small RNAs and the inheritance of histone marks may also contribute to epigenetic inheritance and reprogramming. Reprogramming occurs in flowering plants and in mammals, and the similarities and differences illuminate developmental and reproductive strategies.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/40d4e3a6aeee24e47bff440dc4fba6308beddecf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. W. Dean
5. Jörn Walter
6. Felix Krueger
7. Fátima Santos
8. Simon R. Andrews

In Plant Science

1. Yi Zhang
2. Hao Wu
3. Carlos M. Duarte
4. E. Serrão
5. Felix Krueger
6. Simon R. Andrews
7. G. Pearson
8. B. Pogson

Citations in the corpus

• Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics (2016, background): “In animals, epigenetic reprogramming and resetting occur during gamete formation and sexual reproduction, including the remodeling of histones and their modifications and demethylation of methylated DNA (58).”
• Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells (2011, background): “Recent whole-genome analyses have provided insights into the complexity of methylation patterns in plant and animal species (Farthing et al., 2008; Feng et al., 2010a; Lister et al., 2009; Meissner et al., 2008; Zemach et al., 2010).”
• Transcriptional Regulation and its Misregulation in Disease (2013, neutral): “Another type of repressed chromatin is found in regions of the genome that are fully silenced, such as that containing retrotransposons and other repetitive elements (Feng et al., 2010; Lejeune and Allshire, 2011).”
• Epigenetics and the environment: emerging patterns and implications (2012, neutral): “Histone modifications, and possibly also DNA methylatio”
• Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “For example, DNA demethylation is important for primordial germ cells (PGCs) to gain pluripotent ability.(79,80) DNA demethylation is actively regulated by the TET protein family (teneleven translocation enzymes, TET1-3) via the removal of a methyl group from 5-mC.”
• The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “, 2011), suggesting that active and passive mechanisms of demethylation work in concert to ensure robust epigenetic reprogramming in PGCs (Feng et al., 2010; Saitou et al., 2011; Hackett et al., 2012b).”
• Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “During early development, the mammalian DNA methylome is dramatically reprogrammed at two stages (Feng et al., 2010b; Gehring et al., 2009).”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “…PGC proliferation kinetics have led to an intense investigation of active DNA demethylation mechanisms in these cells (Hajkova et al. 2008, 2010; Feng et al. 2010; Popp et al. 2010; Wu and Zhang 2010; Cortellino et al. 2011; Dawlaty et al. 2011, 2013; Yamaguchi et al. 2012, 2013, 2014; Hackett…”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “…Tet3-mediated 5mC oxidation in zygotic DNA demethylation While DNA methylation patterns are relatively stable in somatic cells, rapid erasure of global DNA methylation patterns has been observed in developing PGCs as well as zygotes (Sasaki and Matsui 2008; S Feng et al. 2010; Wu and Zhang 2010).”
• Linking epigenetics and biological conservation: Towards a conservation epigenetics perspective (2019, neutral): “…The heterogeneity in genome-wide DNA methylation patterns and reprogrammation among the tree of life has already received considerable attention, and several valuable reviews exist on this topic (Feng, Jacobsen, & Reik, 2010; Head, 2014; Hunt, Glastad, Yi, & Goodisman, 2013; Law & Jacobsen, 2010).”