Genome-wide mapping and analysis of chromosome architecture

By Anthony D. Schmitt, Ming Hu, Bing Ren. Nature reviews. Molecular cell biology, 2016

339 citations recorded by the source corpus.

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA replication, transcription and the repair of DNA damage. Thus, a thorough understanding of nuclear architecture is fundamental to the study of nuclear processes in eukaryotic cells. Recent years have seen rapid proliferation of technologies to investigate genome organization and function. Here, we review experimental and computational methodologies for 3D genome analysis, with special focus on recent advances in high-throughput chromatin conformation capture (3C) techniques and data analysis.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/40a67bddcfb77cede59ee9fd44acde7f9d03925f

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Citations in the corpus

• Hierarchical cooperation of transcription factors from integration analysis of DNA sequences, ChIP-Seq and ChIA-PET data (2019, background): “The structure of genomic DNA can be compartmentalized into four hierarchical structures [6 – 8] with different resolutions: chromosome territories (50 – 250 MB bases), A/B compartments (~ 5 MB bases), topologically associated domains (TADs) (~ 1 MB) or sub-TADs (0.1 – 1 MB), and chromatin loops (5…”