Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel.

By M. Yamada, M. Nakashima, M. Seki. Analytical Chemistry, 2004

751 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Computational Mechanics

View Paper: https://www.semanticscholar.org/paper/409cd4362a92251369d2c6def2cab1c580b536ab

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In Biomedical Engineering

In Computational Mechanics

Citations in the corpus

Blood-on-a-chip. (2005, background): “Segregation was increased even further when the flow stream spread again in a larger channel, with larger particles aligned toward the center and smaller particles pushed toward the walls (16).”
A review of microfabrication techniques and dielectrophoretic microdevices for particle manipulation and separation (2014, background): “(3) The hydrodynamic technique presumes that particles will follow the fluid streamlines at a low Reynolds number, which has been applied within microchannels having multiple side branch channels [43], a pinched segment [44], or micro-obstacle arrays [45], and the separation of different-sized polys”
Point-of-care diagnostics for global health. (2008, methodology): “Some new techniques, such as pinched-flow fractionation, show particular promise in simply but effectively fractionating cells by size (175).”
Label-free cell separation and sorting in microfluidic systems (2010, methodology): “proposed pinched flow fractionation, a purely hydrodynamic method of fractionating a sample by size [42].”
Inertial microfluidics for continuous particle filtration and extraction (2009, methodology): “This has triggered the recent developments of many microscale membrane-free filtration methods for efficient and cost-effective particle filtration, including field-flow fractionation and electrophoresis (Giddings 1993; Yamada et al. 2004; Fuh and Giddings 1997; Chmela et al. 2002; Wei et al. 1999”
Particle inertial focusing and its mechanism in a serpentine microchannel (2014, methodology): “Active techniques such as dielectrophoresis (DEP) (Çetin and Li 2011), magnetophoresis 30 (MP) (Forbes and Forry 2012) and acoustophoresis (AP) (Wang and Zhe 2011) rely on an external force field, whereas passive techniques depend entirely on the channel geometry or intrinsic hydrodynamic forces, su”
Microfluidics for cell separation (2010, methodology): “The technique was employed to achieve separation of a mixture of 15 and 30 lm polystyrene particles [116].”
Microfluidic bio-particle manipulation for biotechnology (2014, background): “If 3D structures are both on the bottom and the top wall, lithographic aligning procedure is required [27,28].”