Cytomegalovirus Seropositivity Drives the CD8 T Cell Repertoire Toward Greater Clonality in Healthy Elderly Individuals1

By N. Khan, N. Shariff, M. Cobbold, R. Bruton, J. Ainsworth, A. Sinclair, L. Nayak, P. Moss. Journal of Immunology, 2002

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Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “In older people, one or a few clonal populations can occupy more than 25% of the entire CD8 cell pool (46, 51).”
Immunobiology of Human Cytomegalovirus: from Bench to Bedside (2009, background): “In striking contrast, an accumulation of HCMV-specific CD8 T cells occurs with age, such that it may represent over 40% of the CD8 T-cell pool (128, 129, 188).”
Immunosenescence: molecular mechanisms and diseases (2023, background): “found that latent cytomegalovirus-infected individuals have a reduced pool of naïve and early memory T cells and clonal expansions of CD8 T cells with a CD28CD57 phenotype, resulting in a decline in T-cell responses.(61,62) Similar T-cell alterations have been identified in the TME of multiple tumor”