Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status.

By F. Trevisani, P. E. D'Intino, A. Morselli-Labate, G. Mazzella, E. Accogli, P. Caraceni, M. Domenicali, S. D. Notariis, E. Roda, M. Bernardi. Journal of Hepatology, 2001

734 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/403f8c95642b98921b914587aa8f1fe768ddb60e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jordi Bruix1 , 2
2. J. Llovet
3. V. Mazzaferro
4. Peter R. Galle
5. Andrew X. Zhu
6. Riccardo Lencioni
7. Alejandro Forner1 , 2
8. D. Sarkar

In Hepatology

1. J. Llovet
2. Jordi Bruix1 , 2
3. Riccardo Lencioni
4. V. Mazzaferro
5. Alejandro Forner1 , 2
6. Andrew X. Zhu
7. Peter R. Galle
8. T. de Baère

Citations in the corpus

• Management of hepatocellular carcinoma: An update (2011, neutral): “5%, and even at a cut-off of 400 ng/ mL the PPV is only 60%.(38) In cohorts undergoing surveillance the incidence of HCC may be even lower than 5%, depending on the criteria for entry into surveillance.”
• Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification (2020, background): “Although controversial, AFP is the most commonly used serum biomarker for HCC and expressed in 60% of HCC patients (Trevisani et al., 2001).”
• EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, methodology): “When used as a diagnostic test, AFP levels at a value of 20 ng/ml show good sensitivity but low specificity, whereas at higher cut-offs of 200 ng/ml the sensitivity drops to 22% with high specificity [80].”
• EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. (2018, background): “When used as a diagnostic test, AFP levels at a value of 20 ng/ml show good sensitivity but low specificity, whereas at higher cut-offs of 200 ng/ml the sensitivity drops to 22% with high specificity.(134) However, such information was mostly obtained in viraemic patients, in whom active hepatitis m”
• EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, methodology): “When used as a diagnostic test, AFP levels at a value of 20 ng/ml show good sensitivity but low specificity, whereas at higher cut-offs of 200 ng/ml the sensitivity drops to 22% with high specificity [80].”