Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets.

By Bo Zheng, L. Roach, R. Ismagilov. Journal of the American Chemical Society, 2003

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Continuous generation of hydrogel beads and encapsulation of biological materials using a microfluidic droplet-merging channel (2008, background): “Droplet-based mixing is usually achieved by injecting multiple liquids altogether to the same inlet to form droplets (Song et al. 2003; Tice et al. 2003; Zheng et al. 2003 ).”
Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. (2010, background): “Protein crystallization, for example, is realized on the segmented flow platform by forming droplets out of three liquids, namely the protein solution, a buffer and the precipitant within oil as the carrier phase [176, 182].”
Microfluidics: Fluid physics at the nanoliter scale (2005, background): “…kinetics on millisecond time scales by injecting reactive chemicals together to form drops Song, Bringer, et al., 2003; Song and Ismagilov, 2003; Song, Tice, et al., 2003; Tice et al., 2003; Bringer et al., 2004 , and in developing a platform for protein crystallization Zheng et al., 2003 .”