Cytochromes P450 and metabolism of xenobiotics

By P. Anzenbacher, E. Anzenbacherová. Cellular and Molecular Life Sciences (CMLS), 2001

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Microbial Enzymes Used in Bioremediation (2021, background): “P450s have an intrinsic capacity to degrade xenobiotics [35] through chemical transformations like aliphatic hydroxylations and epoxidations, dealkylations, dehalogenation, and various mechanism-based inactivations that are central to bioremediation chemistry.”
Crystal structure of human cytochrome P450 2C9 with bound warfarin (2003, background): “Mammalian CYP450s recognize and metabolize diverse xenobiotics such as drug molecules, environmental compounds and pollutant”
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life (2005, background): “Liver is the major organ for xenobiotic metabolism (Anzenbacher and Anzenbacherova, 2001; Jaeschke et al., 2002) and is also the major organ for iron transport and storage (Crichton et al., 2002; Fletcher and Halliday, 2002).”
Microbial biodegradation of polyaromatic hydrocarbons. (2008, background): “All seven genes of the CYP63 family of proteins showed differential transcriptional induction with alkanes and their derivatives (Anzenbacher & Anzenbacherova , 2001).”