Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis

By O. Patel, Rajini Brammananth, Weiwen Dai, S. Panjikar, R. Coppel, I. Lucet, Paul K. Crellin. 2022

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The first crystal structure of the putative cell-wall biosynthesis protein LmcA from Mycobacterium smegmatis is reported at 1.8 Å resolution. The structure revealed an elongated β-barrel fold enclosing two distinct cavities, indicating a possible lipid-binding function in lipomannan/lipoarabinomannan biosynthesis.

Subfields: Genetics, Infectious Diseases, Organic Chemistry