Mast cells

By J. Marshall, J. Bienenstock. Springer Seminars in Immunopathology, 2004

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The role of mast cells in allergic inflammation. (2012, background): “This leaves their Fab, or antigen binding segment, free to bind the antigen.(9,13,15,16) A subsequent exposure to the same allergen cross-links the cell-bound IgE and triggers the release of preformed prostaglandins, histamines and cytokines (Fig.”
Histamine in the nervous system. (2008, background): “Compound 48/ 80, a basic polymer, causes exocytosis of mast cell granular content but not of histamine from axonal varicosities (157, 467) and thus can differentiate histamine release from nonneuronal and neuronal resources.”