Akt in cancer: Mediator and more.

By Sundaramoorthy Revathidevi, Arasambattu Kannan Munirajan. Seminars in Cancer Biology, 2019

628 citations recorded by the source corpus.

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling pathway. The Akt can be activated by a wide range of growth signals and the biochemical mechanisms leading to Akt activation are well defined. Once activated, Akt modulates the function of many downstream proteins involved in cellular survival, proliferation, migration, metabolism, and angiogenesis. The Akt is a central node of many signaling pathways and it is frequently deregulated in many types of human cancers. In this review, we provide an overview of Akt function and its role in the hallmarks of human cancer. We also discussed various mechanisms of Akt dysregulation in cancers, including epigenetic modifications like methylation, post-transcriptional non-coding RNAs-mediated regulation, and the overexpression and mutation.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3fb18c6451ded102d4f47eb65d4b5c215f73a45e

Citations in the corpus

• Current landscape and future directions of therapeutic approaches for adenoid cystic carcinoma of the salivary glands (Review) (2025, unknown): “AKT serves a pivotal role in various signaling pathways and is often dysregulated in numerous types of human cancer (139).”