Community-associated methicillin-resistant Staphylococcus aureus
By F. DeLeo, M. Otto, B. Kreiswirth, Henry F. Chambers. The Lancet, 2010
1,217 citations recorded by the source corpus.
Summary Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide and a significant cause of morbidity and mortality. Healthcare-associated MRSA infections occur in individuals with predisposing risk factors for disease, such as surgery or presence of an indwelling medical device. By contrast, community-associated MRSA (CA-MRSA) infections often occur in otherwise healthy individuals who lack such risk factors. In addition, CA-MRSA infections are epidemic in some countries. These observations suggest that CA-MRSA strains are more virulent and transmissible than traditional hospital-associated MRSA strains. Relatively limited treatment options for CA-MRSA infections compound the problem of enhanced virulence and transmission. Although progress has been made toward understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge in these areas remains incomplete. Here were review the most current knowledge in these areas and provide perspective on future outlook for prophylaxis and/or new therapies for CA-MRSA infections.
Subfields: Clinical Biochemistry, Infectious Diseases, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/edf553c7710af8d554a765ea682b183d67c6b8d0
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In Clinical Biochemistry
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Citations in the corpus
- Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “DistinctMRSA strains are endemic to particular geographical regions while some strains have spread globally (DeLeo et al. 2010; Uhlemann et al. 2014).”