Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?

By G. M. Escobar, M. Obregon, F. E. D. Rey. Journal of Clinical Endocrinology and Metabolism, 2000

681 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Thyroid hormone receptors in brain development and function (2007, background): “A discussion on the effects of maternal hypothyroidism on human fetal development is out of the scope of the present article but has been the subject of previous reviews”
Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3‐year follow‐up study (2003, neutral): “However, there is growing concern that hypothyroxinaemia during early gestation could be harmful to the offspring (Pop et al ., 1999b; Utiger, 1999; Morreale de Escobar et al ., 2000).”
Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association (2012, neutral): “Studies of fetal development and at least one outcome study done in Europe suggest that early central nervous system development requires adequate transplacental T 4 transport (226–231).”
A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. (2004, background): “…consequences ensuing from maternal hypothyroidism and early childhood hormone deprivation have been documented in endemic areas of iodine deficiency (Delange 2000) and in inherited and acquired hypothyroidism occurring with high frequency in the Western world (Morreale de Escobar et al. 2000).”