Formation of new chromatin domains determines pathogenicity of genomic duplications

By Martin Franke, Daniel M. Ibrahim, G. Andrey, Wibke Schwarzer, V. Heinrich, R. Schöpflin, K. Kraft, Rieke Kempfer, I. Jerković, W. Chan and 13 more. Nature, 2016

614 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/3ef317ef524e11e35f3426c2927e27ac4fc9f177

Citations in the corpus

• Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization (2017, neutral): “This highlights the crucial role of boundaries in mediating the physical insulation of neighboring chromosome domains, with important implications for disease-causing chromosomal rearrangements in humans (Flavahan et al., 2016; Franke et al., 2016; Hnisz et al., 2016).”