Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

By Anders Folkesson, L. Jelsbak, Lei Yang, H. Johansen, O. Ciofu, Niels Høiby, Søren Molin. Nature Reviews Microbiology, 2012

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Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections (2016, background): “Mutations occuring early in the infection, and therefore presumably the most beneficial, are located in global regulatory network control hubs [33], with other mutations occurring later and leading to fine-tuning [33].”
Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy (2019, background): “Hospitals employ a broad range of antibiotics over extended time spans, thus enabling de novo resistance evolution, for example during long-term treatment of chronic infections [68].”
Pseudomonas aeruginosa Biofilms (2020, background): “The mucoid phenotypes are found mostly in CF isolates, signifying the conversion from acute to chronic infection [36,37].”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “On the other hand, some studies showed that CF-infecting strains with the common lasR loss-of-function mutations were more resistant to therapeutic antibiotics such as tobramycin, ciprofloxacin and ceftazidime.”