Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer
By Yu Cheng, A. Samia, Joseph D. Meyers, I. Panagopoulos, Baowei Fei, C. Burda. Journal of the American Chemical Society, 2008
690 citations recorded by the source corpus.
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible “cage” that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP–Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
Subfields: Biomaterials, Biomedical Engineering, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/3eaf5731c5a478ec9d5ba75f55e7f4b3733e2d9c
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In Biomaterials
In Biomedical Engineering
Citations in the corpus
- Optical properties and biomedical applications of plasmonic nanoparticles (2010, background): “Targeted delivery of conjugated NPs could improve the therapeutic efficiency of known technologies as photodynamic therapy [279] and new emerged field called plasmonic photothermal therapy (PPTT) [11].”
- Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer (2018, background): “Nevertheless, some studies do show that these photosensitizers can be conjugated to the gold nanoparticles, thereby facilitating their uptake and delivery to the cancer tissues [57].”