Distributions of Exons and Introns in the Human Genome
By M. Sakharkar, V. Chow, Pandjassarame Kangueane. Silico Biol., 2004
345 citations recorded by the source corpus.
The human genome is revisited using exon and intron distribution profiles. The 26,564 annotated genes in the human genome (build October, 2003) contain 233,785 exons and 207,344 introns. On average, there are 8.8 exons and 7.8 introns per gene. About 80% of the exons on each chromosome are < 200 bp in length. < 0.01% of the introns are < 20 bp in length and < 10% of introns are more than 11,000 bp in length. These results suggest constraints on the splicing machinery to splice out very long or very short introns and provide insight to optimal intron length selection. Interestingly, the total length in introns and intergenic DNA on each chromosome is significantly correlated to the determined chromosome size with a coefficient of correlation r = 0.95 and r = 0.97, respectively. These results suggest their implication in genome design.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/3e320b97a2afae99c99bd7ad5362604e6339212e
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Citations in the corpus
- Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “For example the ratio of intron to exon length in the human genome is about 28 (69) and the length of mature rRNAs are about 50% of the pre rRNA transcript (70).”
- Utilization of next-generation sequencing platforms in plant genomics and genetic variant discovery (2010, background): “While plant genes are significantly smaller on average relative to mammalian genes (Sakharkar et al. 2004; Ren et al. 2006), the wide variation of genome size among plant species is due to the occurrence of both polyploidy and the elevated content of highly repetitive DNA sequences primarily due to…”