Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta‐analysis

By S. Ballestri, S. Zona, G. Targher, D. Romagnoli, E. Baldelli, Fabio Nascimbeni, A. Roverato, G. Guaraldi, A. Lonardo. Journal of Gastroenterology and Hepatology, 2016

637 citations recorded by the source corpus.

The magnitude of the risk of incident type 2 diabetes (T2D) and metabolic syndrome (MetS) among patients with nonalcoholic fatty liver disease (NAFLD) is poorly known. We gauged the risk of developing T2D and MetS in patients with NAFLD diagnosed by either serum liver enzymes (aminotransferases or gamma‐glutamyltransferase [GGT]) or ultrasonography.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/3e218c11d01163e4d2b856a34ef4c78919fc00c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. G. Targher
2. Z. Younossi
3. Herbert Tilg
4. A. Lonardo
5. Fabio Nascimbeni
6. Q. Anstee
7. A. Mantovani
8. L. Adams

In Epidemiology

1. G. Targher
2. Z. Younossi
3. Herbert Tilg
4. Q. Anstee
5. A. Lonardo
6. Fabio Nascimbeni
7. A. Mantovani
8. L. Adams

In Hepatology

1. Z. Younossi
2. Q. Anstee
3. Herbert Tilg
4. A. Lonardo
5. G. Targher

Citations in the corpus

• Epidemiology of metabolic dysfunction-associated steatotic liver disease (2024, methodology): “[ 52,53] In a recent meta-analysis of MASLD prevalence among those with T2D, investigators determined that the MASLD prevalence for the years 2016-2021 was 68.8% an increase of 13% from 1990-2004 (55.6%).”
• Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases (2017, background): “117 Nevertheless, serum aminotransferase levels are relatively insensitive markers of NAFLD.”
• Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence? (2018, background): “almost 117,000 nondiabetic individuals from 20 observational studies concluded that NAFLD, detected by either abnormal serum liver enzymes or ultrasonography, was associated with a nearly twofold increase in the risk of incident T2DM over a median follow-up of five years.(22) Recently, the largest p”