Gut mucosal microbiome across stages of colorectal carcinogenesis
By Geicho Nakatsu, Xiangchun Li, Haokui Zhou, J. Sheng, S. Wong, W. Wu, S. Ng, H. Tsoi, Yujuan Dong, Ning Zhang and 8 more. Nature Communications, 2015
618 citations recorded by the source corpus.
Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC. Changes in gut microbial communities contribute to the development of colorectal cancer. Here, the authors analyse the gut mucosal microbiome of patients and healthy subjects and identify distinct microbial consortia associated with different stages of colorectal cancer tumorigenesis.
Subfields: Molecular Biology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/3d9ca129df7eca81a188216ea05eedf76db82d5b
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In Molecular Biology
Citations in the corpus
- Mucosal microbiome dysbiosis in gastric carcinogenesis (2017, background): “28 Correlation strengths of GC-enriched and GC-depleted bacteria increased with disease progression After correcting for spurious correlations and FDR adjustments, we observed that both co-occurrence and co-excluding interactions among GC-enriched and GC-depleted OTUs were significantly different…”