Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.

By R. Kroes, A. Renwick, V. J. Feron, Corrado L. Galli, Michael J. Gibney, Helmut Greim, Richard H. Guy, J. Lhuguenot, J. V. D. Sandt. Food and Chemical Toxicology, 2007

1,390 citations recorded by the source corpus.

Subfields: Dermatology, Health, Toxicology and Mutagenesis, Plant Science

View Paper: https://www.semanticscholar.org/paper/3d57b1b87a3c3677541a097f0e81b96b49e2c7cf

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Citations in the corpus

• Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients. (2015, positive): “the use of default skin penetration values (Blackburn et al., 2005; Kroes et al., 2007).”
• Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment. (2015, background): “Recently, the TTC approach was extended to the safety evaluation of topically applied cosmetic ingredients, including fragrance materials (Blackburn et al., 2005; Kroes et al., 2007).”
• An evaluation of the implementation of the Cramer classification scheme in the Toxtree software (2008, positive): “More recently the approach has been applied to evaluate impurities in pharmaceuticals [6–8], cosmetic ingredients [9] as well as personal and household care products [10].”