Toward a detailed computational model for the mammalian circadian clock

By J. Leloup, Albert Goldbeter. Proceedings of the National Academy of Sciences of the United States of America, 2003

583 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3cd5052370b6af16ba2d1735c08524dbdbd59a4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. J. Takahashi
2. C. H. Ko
3. Ethan D. Buhr
4. David K. Welsh
5. A. C. Liu
6. Steve A. Kay
7. Hien G. Tran
8. E. E. Zhang

Citations in the corpus

• Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, methodology): “We modified a published computational clock model (Leloup and Goldbeter, 2003) to reproduce the largely arrhythmic behavior of the individual Per1 / and Cry1 / neurons by introducing noise to the Bmal1 degradation rate and to the activation threshold of nuclear BMAL1 on Cry transcription.”