Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

By Andrew V. Anzalone, Luke W. Koblan, David R. Liu. Nature Biotechnology, 2020

1,817 citations recorded by the source corpus.

Subfields: Business and International Management, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c905c3670afa37c4596066400ae4316ce43ef90

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Business and International Management

1. Caixia Gao

In Genetics

1. Caixia Gao
2. Mustafa Sahin
3. Howard Y. Chang
4. David R. Liu
5. Jonathan S. Weissman
6. Bradley E. Bernstein

In Molecular Biology

1. Caixia Gao
2. Howard Y. Chang
3. Luke A. Gilbert
4. Gregory A. Newby
5. Britt Adamson
6. Jonathan S. Weissman
7. Mustafa Sahin
8. David R. Liu

Citations in the corpus

• Genome-wide Programmable Transcriptional Memory by CRISPR-based Epigenome Editing (2021, background): “Additionally, base and prime editing strategies allow for precise DNA sequence modifications but generally rely on one or more DNA single strand nicks (Anzalone et al., 2020).”
• Enhanced prime editing systems by manipulating cellular determinants of editing outcomes (2021, background): “Toward the goal of enabling a wide range of sequence changes, we developed prime editing, a versatile gene editing approach that can install all types of targeted DNA base pair substitutions, small insertions, small deletions, and combinations thereof without requiring double-strand DNA breaks (DSBs”
• Genome engineering for crop improvement and future agriculture. (2021, positive): “In addition, recently developed CRISPR-associated tools such as base editors and prime editors have greatly expanded the scope of genome editing (Anzalone et al., 2020), allowing for the creation of precise nucleotide substitutions and targeted DNA deletions and insertions.”