Optimization protocols and improved strategies for metal-organic frameworks for immobilizing enzymes: Current development and future challenges

By J. Cui, Sizhu Ren, Baoting Sun, Shiru Jia. Coordination chemistry reviews, 2018

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Abstract Metal-organic frameworks (MOFs) are a type of porous material that have tunable porosity, desirable functionality, extremely high surface area, and chemical/thermal stability. MOFs consist of metal containing nodes and organic ligands linked through coordination bonds. Owing to the unique properties of MOFs, there is considerable interest in using them as a potential matrix for enzyme immobilization. Recent studies have focused on developing enzyme-MOF composites with potential applications. Many MOF-enzyme composites exhibit excellent catalytic performance, far outperforming free enzymes in many aspects. This review summarizes recent developments in enzyme-MOF composites with special emphasis on novel synthesizing strategies, process optimization, and improvement of catalytic performance of the enzyme-MOF composites over free enzymes.

Subfields: Inorganic Chemistry, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c7e353798ab7a8768637ded2e0543151458a523