Mucoadhesive drug delivery systems
By Doran Donnelly, R. Shaikh, T. Raghu, Rajkumar Singh, Martin James, A. Woolfson. Journal of Pharmacy and Bioallied Sciences, 2011
998 citations recorded by the source corpus.
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).
Subfields: Pharmaceutical Science, Pharmacy
View Paper: https://www.semanticscholar.org/paper/3c3b8d81e12d7e14af34777ef43ff6ea9be19bf8
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In Pharmaceutical Science
Citations in the corpus
- Advances in oral transmucosal drug delivery. (2011, background): “At physiological pH, the mucus network carries a negative charge due to the sialic acid and sulfate residues and forms a strongly cohesive gels structure that will bind to the epithelial cell surface as a gelatinous layer [30-32].”