Biodegradable synthetic polymers for tissue engineering.

By P. Gunatillake, R. Adhikari. European Cells & Materials, 2003

1,645 citations recorded by the source corpus.

This paper reviews biodegradable synthetic polymers focusing on their potential in tissue engineering applications. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Some disadvantages of these polymers in tissue engineering applications are their poor biocompatibility, release of acidic degradation products, poor processability and loss of mechanical properties very early during degradation. Other degradable polymers such as polyorthoesters, polyanhydrides, polyphosphazenes, and polyurethanes are also discussed and their advantages and disadvantages summarised. With advancements in tissue engineering it has become necessary to develop polymers that meet more demanding requirements. Recent work has focused on developing injectable polymer compositions based on poly (propylene fumarate) and poly (anhydrides) to meet these requirements in orthopaedic tissue engineering. Polyurethanes have received recent attention for development of degradable polymers because of their great potential in tailoring polymer structure to achieve mechanical properties and biodegradability to suit a variety of applications.

Subfields: Biomaterials, Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/3c198abeb7bda004e9f9994d9751a8b8a564d326

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Citations in the corpus

Biodegradable Materials for Bone Repair and Tissue Engineering Applications (2015, background): “Although PLGA has been extensive used in a variety of clinical applications, its use is limited in the field of orthopedics [262].”
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. (2006, background): “Surface erodative polymers Poly(anhydrides) [31,40,41] 150–200 Surface 25–27 0.”
Polymeric composites for powder-based additive manufacturing: Materials and applications (2019, neutral): “, polyvinyl alcohol (PVA), poly- ε -caprolactone (PCL), poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), polylactide (PLA), polyglycolide (PGA), and their co-polymers [69,70].”
Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications. (2016, background): “PLA is highly biocompatible, semi crystalline and hydrophobic in nature [24].”
Microbial enzymes: industrial progress in 21st century (2016, background): “Biopolymers, such as polyesters, polycarbonates and polyphosphates are used in various biomedical applications, e.g., orthopedic devices, tissue engineering, adhesion barriers, control drug delivery, etc. (Gunatillake and Adhikari 2003; Ulery et al. 2011).”
Review of Multifarious Applications of Poly (Lactic Acid) (2016, background): “to suit various applications, and the ability to fabricate into various shapes with desired pore morphologic features([108,122]).”