Glycosylation regulates Notch signalling

By Nicola Haines, Kenneth D. Irvine. Nature reviews. Molecular cell biology, 2003

611 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3bf53c825c9f8bd2f8cfc80146e83c5bca4d30aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Fortini
2. K. Ohtsubo
3. J. Marth
4. A. Varki

In Molecular Biology

1. M. Ilagan
2. Raphael Kopan
3. M. Fortini
4. K. Ohtsubo
5. J. Marth
6. A. Varki

Citations in the corpus

• Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “Glycosylation: Implications for Notch Folding and Function The extracellular domains of Notch and its DSL ligands contain numerous potential sites for N-linked and O-linked glycosylation (reviewed in Haines and Irvine, 2003; Vodovar and Schweisguth, 2008).”
• Glycosylation in cellular mechanisms of health and disease. (2006, background): “For example, Notch receptor trafficking , ligand binding, and activation is regulated by an O-fucose linkage produced in the endoplasmic reticulum and elaborated further in the Golgi by the Fringe glycosyltransferase (Haines and Irvine, 2003).”
• The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism (2009, background): “As Ofut1 and Rumi both appear to function cell autonomously in signal-receiving cells, the biological function of glycosylation in the Notch pathway is largely centered on receptor modulation (Haines and Irvine, 2003; Stanley, 2007).”