VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

By S. Stacker, C. Caesar, M. Baldwin, G. E. Thornton, R. Williams, R. Prevo, D. Jackson, S. Nishikawa, H. Kubo, M. Achen. Nature Medicine, 2001

1,273 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3be824d641381f6b077e8c11361034a752df664c

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In Molecular Biology

1. J. Joyce
2. E. Nakasone
3. K. Alitalo
4. M. Egeblad
5. Peter Carmeliet
6. Zena Werb
7. Michael Detmar
8. L. Brown

In Oncology

1. Zena Werb
2. M. Egeblad
3. E. Nakasone
4. Peter Carmeliet
5. K. Alitalo
6. J. Joyce
7. Pengfei Lu
8. R. Weinberg

Citations in the corpus

• VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis (2005, background): “In contrast, a previous study of VEGFA–transfected human 293 cell xenotransplants did not detect promotion of tumor lymphangiogenesis (4).”
• Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “Indeed, depending on the molecular markers used to label putative lymphatic vessels and the tumor model or type used to study tumor lymphangiogenesis, intratumoral lymphatic vessels were documented in tumor xenografts overexpressing VEGF-C or VEGF-D (Karpanen et al., 2001; Skobe et al., 2001; Stacke”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “and promote metastasis to lymph nodes (Skobe et al., 2001; Stacker et al., 2001).”
• Therapeutic targeting of the tumor microenvironment. (2005, positive): “Similarly, interfering with tumor lymphangiogenesis using a soluble VEGFR3 inhibitor (He et al., 2002) or a VEGF-C antibody (Stacker et al., 2001) resulted in decreased lymph node metastases (see Achen et al., 2005 for F O C U S review).”
• Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “The correlation of VEGF-D and intratumoral lymphangiogenesis was further investigated in VEGF-D overexpressing breast cancer xenografts by Stacker et al. (2001), who observed well defined lymphatic vessels throughout the tumor at a much higher density than in non-VEGF-D expressing tumors, in…”