Comparison of 10-mg and 5-mg Warfarin Initiation Nomograms Together with Low-Molecular-Weight Heparin for Outpatient Treatment of Acute Venous Thromboembolism

By M. Kovacs, M. Rodger, D. Anderson, B. Morrow, G. Kells, J. Kovacs, E. Boyle, P. Wells. 2003

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Clinical Impact of Bleeding in Patients Taking Oral Anticoagulant Therapy for Venous Thromboembolism (2003, background): “However, randomized, controlled trials that have compared initiation of oral anticoagulant therapy with 10 mg or 5 mg have found no differences in bleeding rates with either dose (63, 64).”
The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. (2018, methodology): “One randomized trial comparing a 10 mg and 5-mg Warfarin Initiation Nomograms for the outpatient treatment of acute VTE suggested the 10 mg scheme to be superior with patients reaching a therapeutic INR faster.(466) However, a meta-analysis found no evidence of superiority of either starting regimen”