Molecular imaging by means of multispectral optoacoustic tomography (MSOT).

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Photoacoustic tomography of blood oxygenation: A mini review (2018, methodology): “To address this issue, multivariable data analysis and matrix factorization algorithms such as principal component analysis (PCA) and independent component analysis (ICA) are adopted for unaided or blind spectral unmixing in quantitative PAT [51,52].”
A review of clinical photoacoustic imaging: Current and future trends (2019, background): “Photoacoustic (PA) imaging (PAI), or optoacoustic imaging, is a hybrid imaging modality that merges optical illumination and ultrasound (US) detection [1,2].”
Volumetric real-time multispectral optoacoustic tomography of biomarkers (2011, methodology): “Multispectral optoacoustic tomography (MSOT) has been developed to address this challenge by identifying biomarkers of distinct optical absorption spectra through several millimeters to centimeters of tissue, using multiwavelength illumination and optoacoustic detectio”