Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial.

By Alexander Zarbock, John A. Kellum, C. Schmidt, H. Van Aken, C. Wempe, H. Pavenstädt, A. Boanta, J. Gerss, M. Meersch. Journal of the American Medical Association (JAMA), 2016

1,033 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Nephrology

View Paper: https://www.semanticscholar.org/paper/3b2a52f35024be2595ad89afcd081bd9fe44ee2b

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In Critical Care and Intensive Care Medicine

In Epidemiology

In Nephrology

Citations in the corpus

Acute kidney injury in sepsis (2017, result): “In contrast, a single-center RCT among mainly surgical patients found that early RRT improved survival [79].”
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. (2018, neutral): “suggest that early RRT improves survival [384-386].”
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “RCTs begin as high-quality evidence that could be downgraded due to limitations in any of the aforementioned categories.”
Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence (2020, neutral): “Early continuous blood purification treatment could reduce renal workload and help to promote the recovery of renal function [64] .”
Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial (2017, background): “As a result, experts in the field of critical care nephrology asked for an implementation of treatment strategies in high risk patients to prevent AKI [15, 16].”