Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.

By Seunggeun Lee, M. Emond, Michael Bamshad, K. Barnes, Mark J. Rieder, Deborah A. Nickerson, D. Christiani, M. Wurfel, Xihong Lin. American Journal of Human Genetics, 2012

1,064 citations recorded by the source corpus.

Subfields: Genetics

View Paper: https://www.semanticscholar.org/paper/3b1f2f37499095597a1eb2fa2aa0ad0f6563f4d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Evangelos Evangelou
2. Eric A. Stone
3. John P. A. Ioannidis
4. Richard A. Gibbs
5. T. Mackay
6. Jason Peiffer
7. Jianming Yu
8. R. Bernardo

Citations in the corpus

• Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines (2014, methodology): “However, they are sensitive to the exact methods used for weighting variants within a gene (Masden and Browning, 2009; Han and Pan, 2010; Wu et al., 2010; 2011; Lee et al., 2012).”
• Meta-analysis methods for genome-wide association studies and beyond (2013, methodology): “SKAT-O is another interesting unified approach with application in small case–control sequencing studies; it maximizes power by adaptively using the data to combine optimally the burden test and non-burden sequence kernel tests 105 .”