Multiple type 2 diabetes susceptibility genes following genome-wide association scan in UK samples
By Eleftheria Zeggini, M. Weedon, C. Lindgren, T. Frayling, K. Elliott, H. Lango, Nicholas J. Timpson, J. Perry, N. W. Rayner, R. Freathy and 16 more. Science, 2007
2,209 citations recorded by the source corpus.
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect. The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes.
Subfields: Genetics, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/3acd41eeafe82b68094fdf0a487d8781b01fb790
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Naomi R. Wray
- Peter M. Visscher
- John P. A. Ioannidis
- Bogdan Pasaniuc
- Michael E. Goddard
- Gonçalo R. Abecasis
- Alkes L Price
- Mark J. Daly
In Molecular Biology
- Manuel Serrano
- M. Blasco
- M. Collado
- Cristen J. Willer
- Yurii S. Aulchenko
- Peter M. Visscher
- Gonçalo R. Abecasis
- Y. Ding
In Surgery
- Manuel Serrano
- Peter Kraft
- Mark J. Daly
- Nick Wareham
- John P. A. Ioannidis
- David Altshuler
- Eleftheria Zeggini
- James B. Meigs
Citations in the corpus
- Cellular senescence in cancer and aging. (2007, positive): “Recently, genetic variants in the INK4a/ARF locus have been linked to various age-associated diseases, including general frailty, heart failure, and type 2 diabetes (Helgadottir et al., 2007; McPherson et al., 2007; Melzer et al., 2007; Saxena et al., 2007; Scott et al., 2007; Zeggini et al., 2007).”
- Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, background): “The susceptibility loci of T2DM have been discovered by genome-wide association studies (GWAS) since early 2007 [15-21].”
- Replication in genome-wide association studies (2009, methodology): “The advent of GWA scans was met by prepublication data sharing between three large-scale studies, the WTCCC, DGI and FUSION scans [56, 57, 59, 73], leading to the formation of the DIAGRAM Consortium (Diabetes Genetics Replication and Meta-analysis).”
- β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans (2008, background): “are involved in cell cycle regulation are linked to risk for type 2 diabetes (37).”