Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study.

By M. Stoler, Mark Schiffman. Journal of the American Medical Association (JAMA), 2001

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The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology (2012, background): “The equivocal nature of the diagnosis of –IN 2, an intermediate category that has no biologic correlate, is thought to represent a mixture of low-grade and precancerous disease that cannot be reliably distinguished based on hematoxylin and eosin (H&E) morphology [10, 75].”
American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. (2012, neutral): “nature, the inter- and intraobserver reproducibility of an ASC-US interpretation is less than that for the reliable, unequivocal cytologic categories of LSIL and high-grade squamous intraepithelial lesion.(81) The current ASCCP recommendation(2) of HPV testing for the management of ASCUS cytology te”