Non-coding RNA networks in cancer
By E. Anastasiadou, Leni S. Jacob, Frank J. Slack. Nature Reviews. Cancer, 2017
1,685 citations recorded by the source corpus.
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3a8ab0958b24177a882a0912e2ddb39d6eb990c1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Molecular Biology
- Guangyan Zhou
- Othman Soufan
- Le Chang
- Jianguo Xia
- Zhang Zhang
- David S. Wishart
- Jasmine Chong
- Igor Sinelnikov
Citations in the corpus
- KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-coding Sequences (2021, background): “51 Nowadays, a growing body of evidence have shown that non-coding sequences, historically 52 thought as “junk” due to few knowledge on their function relative to coding sequences, are 53 recognized as functional elements to play important regulation roles in multiple biological 54 processes [4] and”
- miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology (2020, background): “However, increasing evidence has shown that miRNAs participate in complex networks through interactions with other functional elements to exert effects on cell biology and human diseases (12).”
- Non-coding RNAs in disease: from mechanisms to therapeutics (2023, neutral): “ncRNAs act through diverse mechanisms on target genes and interact with each other, creating a complex and dynamic regulatory RNA network 23 .”