Joint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis

By A. Gelber, M. Hochberg, L. Mead, Nae-Yuh Wang, Fredrick Wigley, M. Klag. Annals of Internal Medicine, 2000

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Etiology of Ankle Osteoarthritis (2009, background): “Older age is considered a risk factor for development of OA [8, 26, 30].”
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes (2013, background): “Joint injuries, including intra-articular fractures, meniscal tears, ligamentous damages, and traumatic cartilage injuries, all increase the risk of progressive joint degeneration that causes post-traumatic OA [71].”
High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. (2004, background): “A prospective study demonstrated that the relative risk of knee OA by age 65 years was increased 3-fold in participants who had a knee injury during adolescence and young adulthood (31).”
Why is Osteoarthritis an Age-Related Disease? (2010, background): “Because OA is rare in young adults and even serious joint injuries usually don't manifest as OA until years later [50], it appears that young joint tissues can compensate, to some degree, to abnormal mechanical stress.”