Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?

By P. Muñoz-Cánoves, C. Schéele, B. K. Pedersen, A. Serrano. The FEBS Journal, 2013

701 citations recorded by the source corpus.

Interleukin (IL)‐6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL‐6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL‐6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL‐6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL‐6. Paradoxically, deleterious actions for IL‐6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implications.

Subfields: Molecular Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/3a3bf8298b557ab16185e3b804befce4acf3b314

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Citations in the corpus

• Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “Exercise is an important stimulus for increased gene expression and production of IL-6 in skeletal muscle, and the majority of circulating IL-6 during exercise originates from contracting muscle, resulting in a 100-fold increase over the normal physiological level [50, 54].”