Roles of TGF-beta in hepatic fibrosis.

By A. Gressner, Ralf Weiskirchen, K. Breitkopf, Steven Dooley. Frontiers in Bioscience, 2002

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Hepatic Stellate Cells and Liver Fibrosis (2013, positive): “…TIMPs (6, 145), however a subgroup of this family, the A Disintegrin and Metalloproteinase-domain proteins (ADAMs) may elude TIMP action and contribute to transforming growth factor beta (TGF-β ) activation (26), the most potent stimulus for collagen I production by stellate cells (91, 116, 296).”
Macrophages: Master Regulators of Inflammation and Fibrosis (2010, background): “In addition to inducing fibrosis, TGF-b may also inhibit inflammation and induce apoptosis.(36) Thus, TGF-b both positively and negatively regulates fibrosis via pathways that are likely governed by the cells producing the cytokine.”
GLUTATHIONE SYNTHESIS (2012, background): “Oxidative stress and glutathione in TGF-β-mediated fibrogenesis.”
Smad3 as a mediator of the fibrotic response (2004, background): “High levels of TGF-b are often found in hepatic fibrosis and it has been implicated as a mediator of fibrosis in many liver diseases (Gressner et al. 2002).”
Liver fibrosis -- from bench to bedside. (2003, background): “[2] Gressner AM, Weiskirchen R, Breitkopf K, Dooley S.”