Release of multifunctional peptides by gastrointestinal digestion of sea cucumber (Isostichopus badionotus)

By J. Pérez-Vega, Leticia Olivera-Castillo, J. A. Gómez-Ruiz, B. Hernández-Ledesma. 2013

83 citations recorded by the source corpus.

Abstract Sea cucumber is a benthic marine organism distributed worldwide and used as food in several Asian countries. The species Isostichopus badionotus is captured intensively off the Yucatan Peninsula, Mexico. Boiled I. badionotus was subjected to in vitro simulated gastrointestinal digestion using pepsin and a pepsin–Corolase PP ® mixture. ACE-inhibitory and radical scavenging activities, iron reducing capacity and cytotoxic effects against colorectal cancer cells were evaluated in the hydrolysates and their ultrafiltered fractions. ACE-inhibitory activity was potent in fractions containing peptides ® ) enzymes (IC 50  = 0.038 ± 0.004 mg/mL). Antioxidant activity was exerted by peptides with low and high molecular weights, depending on hydrolysis method. This is the first report of cytotoxic capacity against colorectal HT-29 cells in peptides from sea cucumber. Sea cucumber hydrolysates and ultrafiltered fractions are potential ingredients for development of functional foods.

Subfields: Aquatic Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/39fb315ccd1123620680352ea8310c477668a98f

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Citations in the corpus

• Bioactive Peptides (2017, background): “Many food hydrolysates have also shown multifunctional bioactive effects [7,176,177], however, their components are unknown.”