Half a century of antipsychotics and still a central role for dopamine D2 receptors.

By Shitij Kapur, David C. Mamo. Progress in Neuro-psychopharmacology and Biological Psychiatry, 2003

660 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Effects of prenatal infection on brain development and behavior: a review of findings from animal models. (2010, neutral): “This may be related to any of the multiple actions of anti-psychotic drugs including the ability to block dopamine D2 receptors, provide neuroprotection or enhance demethylation of gene promoters (Kapur and Mamo, 2003; Lieberman et al., 2008; Guidotti et al., 2009).”
The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, positive): “All drugs currently used to treat schizophrenia mediate their actions through the dopamine D2 receptor.(182) With the exception of aripiprazole, which acts as a partial agonist,”