Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes
By M. Reeves, C. Bushnell, G. Howard, J. Gargano, P. Duncan, Gwendolyn F Lynch, Arya Khatiwoda, L. Lisabeth. Lancet Neurology, 2008
1,275 citations recorded by the source corpus.
Stroke has a greater effect on women than men because women have more events and are less likely to recover. Age-specific stroke rates are higher in men, but, because of their longer life expectancy and much higher incidence at older ages, women have more stroke events than men. With the exception of subarachnoid haemorrhage, there is little evidence of sex differences in stroke subtype or severity. Although several reports found that women are less likely to receive some in-hospital interventions, most differences disappear after age and comorbidities are accounted for. However, sex disparities persist in the use of thrombolytic treatment (with alteplase) and lipid testing. Functional outcomes and quality of life after stroke are consistently poorer in women, despite adjustment for baseline differences in age, prestroke function, and comorbidities. Here, we comprehensively review the epidemiology, clinical presentation, medical care, and outcomes of stroke in women.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/39de3302ff1df56a4ed6384f30e726e91772b909
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- Forecasting the Future of Stroke in the United States: A Policy Statement From the American Heart Association and American Stroke Association (2013, background): “Studies suggest that women are protected by endogenous estrogens; however, clinical trials suggest a higher risk of stroke in postmenopausal women treated with exogenous estrogen and progesterone.(34) Stroke incidence varies by race/ethnicity.”
- Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2014, background): “the aging population, the prevalence of stroke survivors is projected to increase, particularly among elderly women.(4)”
- Sex Bias in Neuroscience and Biomedical Research (2010, neutral): “Women have more stroke events than men over the course of their lives, with poorer functional outcomes and more depression, but in some age groups stroke is more common in men (Reeves et al., 2008).”