The Different Mechanisms of Cancer Drug Resistance: A Brief Review
By B. Mansoori, A. Mohammadi, Sadaf Davudian, Solmaz Shirjang, B. Baradaran. Advanced Pharmaceutical Bulletin, 2017
1,567 citations recorded by the source corpus.
Anticancer drugs resistance is a complex process that arises from altering in the drug targets. Advances in the DNA microarray, proteomics technology and the development of targeted therapies provide the new strategies to overcome the drug resistance. Although a design of the new chemotherapy agents is growing quickly, effective chemotherapy agent has not been discovered against the advanced stage of cancer (such as invasion and metastasis). The cancer cell resistance against the anticancer agents can be due to many factors such as the individual’s genetic differences, especially in tumoral somatic cells. Also, the cancer drug resistance is acquired, the drug resistance can be occurred by different mechanisms, including multi-drug resistance, cell death inhibiting (apoptosis suppression), altering in the drug metabolism, epigenetic and drug targets, enhancing DNA repair and gene amplification. In this review, we outlined the mechanisms of cancer drug resistance and in following, the treatment failures by common chemotherapy agents in the different type of cancers.
Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/39dcce595f2f66ea7684f020b25e0dca1b499732
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “Because of the limited and unspecific serum cancer biomarkers for advanced-stage diagnosis [4] and cancer-related drug resistance, the therapeutic effects for invasion-related and metastasis-related cancers are still very poor [3].”
- Mechanisms of Multidrug Resistance in Cancer Chemotherapy (2020, background): “Despite the fact that DAC does not affect directly the tumor growth, it inhibits DNA methylation which sensitizes the tumor to other chemotherapeutics, including carboplatin, cisplatin, and 5-FU [44].”