Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
By N. Nagarsheth, M. Wicha, W. Zou. Nature reviews. Immunology, 2017
1,861 citations recorded by the source corpus.
The tumour microenvironment is the primary location in which tumour cells and the host immune system interact. Different immune cell subsets are recruited into the tumour microenvironment via interactions between chemokines and chemokine receptors, and these populations have distinct effects on tumour progression and therapeutic outcomes. In this Review, we focus on the main chemokines that are found in the human tumour microenvironment; we elaborate on their patterns of expression, their regulation and their roles in immune cell recruitment and in cancer and stromal cell biology, and we consider how they affect cancer immunity and tumorigenesis. We also discuss the potential of targeting chemokine networks, in combination with other immunotherapies, for the treatment of cancer.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/39c05c336986efa1dac783b7007c7a0e9d240657
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In Oncology
Citations in the corpus
- T Cell Dysfunction in Cancer (2018, background): “Such sculpting can either involve repression of T cell recruitment to the tumor site (Nagarsheth et al., 2017; Peng et al., 2015) or inhibition of the functionality of T cells at that site.”
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy (2019, background): “Numerous chemokines mediate immune cell trafficking 144 , and modulation of chemokine signalling has been explored to enhance T cell localization to tumours (Fig.”