Indinavir concentrations and St John's wort.

By S. Piscitelli, A. Burstein, D. Chaitt, R. Alfaro, J. Falloon. The Lancet, 2000

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The use of complementary and alternative therapies to treat anxiety and depression in the United States. (2001, background): “In vitro studies also suggest that hypericum extracts are potent inducers of hepatic enzymes and are therefore capable of reducing the plasma concentrations of a variety of concomitant prescription medications , such as indinavir for patients with HIV (35, 36).”
St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties (2001, background): “…spontaneous reports (Yue et al 2000) and published case reports (Rey & Walter 1998; Nebel et al 1999; Barone et al 2000; Breidenbach et al 2000; Piscitelli et al 2000; Ruschitzka et al 2000) of interactions between St John’s wort and certain prescribed medicines, leading to a loss of or…”
Interactions Between Herbal Medicines and Prescribed Drugs (2012, neutral): “In addition, 80 clinical trials were retrieved in 78 publications.([76-152]) One clinical trial was found to be published twice.”