Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

By T. Einarson, A. Acs, C. Ludwig, U. H. Panton. Cardiovascular Diabetology, 2018

1,897 citations recorded by the source corpus.

BackgroundCardiovascular disease (CVD) is a common comorbidity in type 2 diabetes (T2DM). CVD’s prevalence has been growing over time.PurposeTo estimate the current prevalence of CVD among adults with T2DM by reviewing literature published within the last 10 years (2007–March 2017).MethodsWe searched Medline, Embase, and proceedings of major scientific meetings for original research documenting the prevalence of CVD in T2DM. CVD included stroke, myocardial infarction, angina pectoris, heart failure, ischemic heart disease, cardiovascular disease, coronary heart disease, atherosclerosis, and cardiovascular death. No restrictions were placed on country of origin or publication language. Two reviewers independently searched for articles and extracted data, adjudicating results through consensus. Data were summarized descriptively. Risk of bias was examined by applying the STROBE checklist.ResultsWe analyzed data from 57 articles with 4,549,481 persons having T2DM. Europe produced the most articles (46%), followed by the Western Pacific/China (21%), and North America (13%). Overall in 4,549,481 persons with T2DM, 52.0% were male, 47.0% were obese, aged 63.6 ± 6.9 years old, with T2DM duration of 10.4 ± 3.7 years. CVD affected 32.2% overall (53 studies, N = 4,289,140); 29.1% had atherosclerosis (4 studies, N = 1153), 21.2% had coronary heart disease (42 articles, N = 3,833,200), 14.9% heart failure (14 studies, N = 601,154), 14.6% angina (4 studies, N = 354,743), 10.0% myocardial infarction (13 studies, N = 3,518,833) and 7.6% stroke (39 studies, N = 3,901,505). CVD was the cause of death in 9.9% of T2DM patients (representing 50.3% of all deaths). Risk of bias was low; 80 ± 12% of STROBE checklist items were adequately addressed.ConclusionsGlobally, overall CVD affects approximately 32.2% of all persons with T2DM. CVD is a major cause of mortality among people with T2DM, accounting for approximately half of all deaths over the study period. Coronary artery disease and stroke were the major contributors.

Subfields: Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/39916278f6be1998db26fb0d8385d265ca0807fc

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In Endocrinology, Diabetes and Metabolism

Citations in the corpus

Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications (2019, background): “At the patient level, treating patients with both CVD and T2DM resulted in a cost increase of $3418–9705 /patient/year compared with treating patients with only T2DM.40”
A data-driven approach to predicting diabetes and cardiovascular disease with machine learning (2019, positive): “A systematic literature review by Einarson et al. [5], the authors concluded that 32.2% of all patients with type 2 diabetes are affected by heart disease.”