The increasing complexity of the ubiquitin code

By Richard G Yau, M. Rapé. Nature Cell Biology, 2016

955 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/394f55518740809c3efd68db71536fba4a806fbc

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In Molecular Biology

1. Wenyi Wei
2. Lei Chen
3. T. Meng
4. Ping Wang
5. Lu Deng

Citations in the corpus

• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “The most well-defined linkage type is K48 ubiquitination and it prepares proteins to be degraded [103, 104].”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “Compared to monoubiquitination, there are many types of polyubiquitination, which can be linked by any lysine residues in Ub (K6, K11, K27, K29, K33, K48 and K63) or through its N-terminal Met.(35,36) Initially, the ubiquitination of the K48 type was considered to be the only polyubiquitination.”
• Proteolysis Targeting Chimeras as Therapeutics and Tools for Biological Discovery (2020, neutral): “These PTMs have a multitude of biological functions that are still being investigated (Komander and Rape, 2012; Yau and Rape, 2016), but the canonical role of K48 polyubiquitin is to signal a protein for destruction via the proteasome (Grice and Nathan, 2016).”